abstract：:Estrogen sulfotransferase (SULT1E1) is a phase II drug-metabolizing enzyme known to catalyze sulfoconjugation of estrogens. 17β-estradiol (E2) plays a pivotal role in attenuating endothelial dysfunction. E2 can be further sulfated to estradiol sulfate (E2S) using SULT1E1. To date, there are no reports of expression an...

journal_title：Molecular and cellular endocrinology

authors： Xu Y,Yang X,Wang Z,Li M,Ning Y,Chen S,Yin L,Li X

更新日期：2013-04-30 00:00:00

abstract：:Cell cholesterol metabolism is a tightly regulated process, dependent in part on activation of nuclear liver X receptors (LXRs) to increase expression of genes mediating removal of excess cholesterol from cells in the reverse cholesterol transport pathway. LXRs are thought to be activated predominantly by oxysterols g...

journal_title：Molecular and cellular endocrinology

authors： Pannu PS,Allahverdian S,Francis GA

更新日期：2013-04-10 00:00:00

abstract：:Nuclear Receptors form a superfamily of 48 transcription factors that exhibit a plethora of functions in steroid hormone signaling, regulation of metabolism, circadian rhythm and cellular differentiation. In this review, we describe our current knowledge on the role of Nuclear Receptors in atherosclerosis, which is a ...

journal_title：Molecular and cellular endocrinology

authors： Kurakula K,Hamers AA,de Waard V,de Vries CJ

更新日期：2013-04-10 00:00:00

abstract：:All mammalian cells rely on adenosine triphosphate (ATP) to maintain function and for survival. The heart has the highest basal ATP demand of any organ due to the necessity for continuous contraction. As such, the ability of the cardiomyocyte to monitor cellular energy status and adapt the supply of substrates to matc...

journal_title：Molecular and cellular endocrinology

authors： Nagendran J,Waller TJ,Dyck JR

更新日期：2013-02-25 00:00:00

abstract：:To identify estrogen-responsive genes, we previously isolated estrogen receptor (ER)-binding DNA fragments from human genomic DNA using a recombinant ER protein. Six DNA fragments, each including a perfect palindromic estrogen response element (ERE), were obtained. The nucleotide sequence of one of the six fragments (...

journal_title：Molecular and cellular endocrinology

authors： Hiroi H,Momoeda M,Watanabe T,Ito M,Ikeda K,Tsutsumi R,Hosokawa Y,Koizumi M,Zenri F,Muramatsu M,Taketani Y,Inoue S

更新日期：2013-01-30 00:00:00

abstract：:Cyclosporin A (CsA), tacrolimus and rapamycin are immunosuppressive agents (IAs) associated with insulin resistance and dyslipidemia, although their molecular effects on lipid metabolism in adipose tissue are unknown. We explored IAs effects on lipolysis, lipid storage and expression of genes involved on lipid metabol...

journal_title：Molecular and cellular endocrinology

authors： Pereira MJ,Palming J,Rizell M,Aureliano M,Carvalho E,Svensson MK,Eriksson JW

更新日期：2013-01-30 00:00:00

abstract：:Reg family proteins are expressed in the pancreas and involved in pancreatitis and islet β-cell growth. In order to explore transcriptional control, we transfected luciferase reporter genes driven by Reg promoters into acinar AR42J and islet MIN6 cells. Dexamethasone (DEX) significantly increased the promoter expressi...

journal_title：Molecular and cellular endocrinology

authors： Luo C,Li B,Liu L,Yin HP,Wang M,Liu JL

更新日期：2013-01-30 00:00:00

abstract：:Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthase. ADMA accumulation, mainly due to a decreased dimethylarginine dimethylaminohydrolase (DDAH) activity, has been related to the development of cardiovascular diseases. We investigate whether estradiol prevents the changes induce...

journal_title：Molecular and cellular endocrinology

authors： Novella S,Laguna-Fernández A,Lázaro-Franco M,Sobrino A,Bueno-Betí C,Tarín JJ,Monsalve E,Sanchís J,Hermenegildo C

更新日期：2013-01-05 00:00:00

abstract：:Activating mutations in the follicle-stimulating hormone (FSH) receptor (FSHR) gene are rarely detected due to the absence of a clearly defined phenotype, particularly in men. We here report the biochemical features of a novel mutation in the first extracellular loop of the FSHR. The mutation (N431I) was detected in a...

journal_title：Molecular and cellular endocrinology

authors： Casas-González P,Scaglia HE,Pérez-Solís MA,Durand G,Scaglia J,Zariñán T,Dias JA,Reiter E,Ulloa-Aguirre A

更新日期：2012-11-25 00:00:00

abstract：:Adrenocortical cancer is a rare malignancy for which current pharmacological therapies are still insufficient. We tested the effect of a novel PI3 kinase - mammalian target of rapamycin dual inhibitor (NVP-BEZ235) on proliferation of the H295R adrenocortical cancer cell line in vitro and grown as xenografts in immunod...

journal_title：Molecular and cellular endocrinology

authors： Doghman M,Lalli E

更新日期：2012-11-25 00:00:00

abstract：:Exendin-4 (Ex-4), a long-acting agonist of glucagon-like peptide-1 receptor, is a novel anti-diabetic drug that prevents β-cells against various toxicities. However, the mechanism and molecules mediating the protection procession of Ex-4 are not fully understood. We investigated the protective effect of Ex-4 against l...

journal_title：Molecular and cellular endocrinology

authors： Hong SW,Lee J,Park SE,Rhee EJ,Park CY,Oh KW,Park SW,Lee WY

更新日期：2012-10-15 00:00:00

abstract：:Sex steroids have been known to play important roles in the homeostasis of human skin, but little is known about their biosyntheses in that tissue. In this study, we characterized the correlation between the concentrations of sex steroids and the expression levels of the factors involved in their synthesis or metaboli...

journal_title：Molecular and cellular endocrinology

authors： Inoue T,Miki Y,Abe K,Hatori M,Hosaka M,Kariya Y,Kakuo S,Fujimura T,Hachiya A,Honma S,Aiba S,Sasano H

更新日期：2012-10-15 00:00:00

abstract：:A cDNA for a prostaglandin E(2) (PGE(2)) receptor subtype 4, EP4b (Ptger4b), was cloned from the medaka ovary. The effect of PGE(2) was examined using COS-7 cells expressing the recombinant Ptger4b protein. An increase in intracellular cAMP levels was observed when the cells were incubated with PGE(2), but the increas...

journal_title：Molecular and cellular endocrinology

authors： Fujimori C,Ogiwara K,Hagiwara A,Takahashi T

更新日期：2012-10-15 00:00:00

abstract：:Since high expression of farnesoid X receptor (FXR) has been detected in glucocorticoid-producing adrenocortical cells, we evaluated the potential role of FXR in adrenal glucocorticoid production. FXR agonist GW4064 increased fasting plasma corticosterone levels (+45%; P<0.01) in C57BL/6 mice, indicative of enhanced a...

journal_title：Molecular and cellular endocrinology

authors： Hoekstra M,van der Sluis RJ,Li Z,Oosterveer MH,Groen AK,Van Berkel TJ

更新日期：2012-10-15 00:00:00

abstract：:It is widely accepted that obesity is a major risk factor for the development of atherosclerosis. In this context, adipose tissue produces a variety of adipokines and releases free fatty acids, contributing to a chronic-low grade inflammation state implicated in vascular complications. In this study, we investigated t...

journal_title：Molecular and cellular endocrinology

authors： Lamers D,Schlich R,Horrighs A,Cramer A,Sell H,Eckel J

更新日期：2012-10-15 00:00:00

abstract：:The number of adipocyte progenitors is determined early in foetal and neonatal development in a process which may be altered by gender and excess nutrient intake, and which in turn determines fat mass in adulthood and the risk of developing obesity. Here we investigate the hypothesis that excess nutrients, in this cas...

journal_title：Molecular and cellular endocrinology

authors： Petrighi Polidori G,Lomax MA,Docherty K

更新日期：2012-09-25 00:00:00

abstract：:The prostate gland is highly dependent on androgens for its development, growth and function. Consequently, the prostatic epithelium predominantly consists of androgen-dependent luminal cells, which express the androgen receptor at high levels. In contrast, androgens are not required for the survival of the androgen-r...

journal_title：Molecular and cellular endocrinology

authors： Oldridge EE,Pellacani D,Collins AT,Maitland NJ

更新日期：2012-09-05 00:00:00

abstract：:This paper reviews work on progesterone and the progesterone receptor (PR) in the mouse mammary gland that has been used extensively as an experimental model. Studies have led to the concept that progesterone controls proliferation and morphogenesis of the luminal epithelium in a tightly orchestrated manner at distinc...

journal_title：Molecular and cellular endocrinology

authors： Obr AE,Edwards DP

更新日期：2012-06-24 00:00:00

abstract：:The present study correlated concentrations of activin A and follistatin in follicular fluid (FF) from human small antral follicles to FF concentrations of AMH, inhibin B, progesterone, and oestradiol and to the mRNA expression of FSH-receptor (FSHR), LH-receptor (LHR), AMH-receptor2 (AMHR2), CYP19a, and androgen-rece...

journal_title：Molecular and cellular endocrinology

authors： Jeppesen JV,Nielsen ME,Kristensen SG,Yding Andersen C

更新日期：2012-06-05 00:00:00

abstract：:FOXL2 is a gene encoding a forkhead transcription factor. Its mutations or misregulation have been shown to cause the blepharophimosis-ptosis-epicanthus inversus (BPES) syndrome and more recently have been associated with the development of Ovarian Granulosa Cell Tumors (OGCT). BPES is a genetic disorder involving mil...

journal_title：Molecular and cellular endocrinology

authors： Caburet S,Georges A,L'Hôte D,Todeschini AL,Benayoun BA,Veitia RA

更新日期：2012-06-05 00:00:00

abstract：:Evidence is accumulating that environmental chemicals (ECs) including endocrine-disrupting compounds (EDCs) can alter female reproductive development, fertility and onset of menopause. While not as clearly defined as in the male, this set of abnormalities may constitute an Ovarian Dysgenesis Syndrome with at least som...

journal_title：Molecular and cellular endocrinology

authors： Fowler PA,Bellingham M,Sinclair KD,Evans NP,Pocar P,Fischer B,Schaedlich K,Schmidt JS,Amezaga MR,Bhattacharya S,Rhind SM,O'Shaughnessy PJ

更新日期：2012-05-22 00:00:00

abstract：:For eutherian mammals a continuum of maternal support insures that development of progeny follows an optimal program. Beginning in utero, such support extends into the early neonatal period when bioactive factors are communicated from mother to offspring in colostrum/milk. Defined as lactocrine signaling, communicatio...

journal_title：Molecular and cellular endocrinology

authors： Bartol FF,Bagnell CA

更新日期：2012-05-06 00:00:00

abstract：:Temperature-dependent sex determination (TSD) is a prime example of phenotypic plasticity in that gonadal sex is determined by the temperature of the incubating egg. In the red-eared slider turtle (Trachemys scripta), the effect of temperature can be overridden by exogenous ligands, i.e., sex steroid hormones and ster...

journal_title：Molecular and cellular endocrinology

authors： Matsumoto Y,Crews D

更新日期：2012-05-06 00:00:00

abstract：:TRESK (TWIK-related spinal cord K(+) channel, KCNK18) belongs to the two-pore domain (K2P) background (leak) potassium channel family. Unlike other K2P channels, TRESK is activated by the calcium signal in heterologous expression systems. The activation is mediated by the calcium/calmodulin-dependent protein phosphata...

journal_title：Molecular and cellular endocrinology

authors： Enyedi P,Braun G,Czirják G

更新日期：2012-04-28 00:00:00

abstract：:β-Cell nutrient sensing depends on mitochondrial function. Oxidation of nutrient-derived metabolites in the mitochondria leads to plasma membrane depolarization, Ca(2+) influx and insulin granule exocytosis. Subsequent mitochondrial Ca(2+) uptake further accelerates metabolism and oxidative phosphorylation. Nutrient a...

journal_title：Molecular and cellular endocrinology

authors： Wiederkehr A,Wollheim CB

更新日期：2012-04-28 00:00:00

abstract：:Fibrosis is one of the key pathological features of airway remodeling in asthma. In the normal airway the amount of collagen and other extracellular matrix components is kept in equilibrium by regulation of synthesis and degradation. In asthma this homeostasis is disrupted due to genetic and environmental factors. In ...

journal_title：Molecular and cellular endocrinology

authors： Royce SG,Cheng V,Samuel CS,Tang ML

更新日期：2012-04-04 00:00:00

abstract：:Patients with PS or non-syndromic deafness were submitted to genetic/functional analyzes of SLC26A4, of its binding domain for FOXI1 (FOXI1-DBD), of the transcription activator FOXI1, and of the potassium channel KCNJ10. SLC26A4 was the most frequently mutated gene. An altered intracellular localization with immunocyt...

journal_title：Molecular and cellular endocrinology

authors： Cirello V,Bazzini C,Vezzoli V,Muzza M,Rodighiero S,Castorina P,Maffini A,Bottà G,Persani L,Beck-Peccoz P,Meyer G,Fugazzola L

更新日期：2012-04-04 00:00:00

abstract：:Liver X receptors (LXR) are members of the nuclear receptor family. As activated transcription factors, their putative association with human diseases makes them promising pharmacological targets because of the large potential to develop ligands. LXR are mainly considered as intracellular cholesterol "sensors" whose a...

journal_title：Molecular and cellular endocrinology

authors： Viennois E,Mouzat K,Dufour J,Morel L,Lobaccaro JM,Baron S

更新日期：2012-04-04 00:00:00

abstract：:Adrenocortical tumor (ACT), a rare tumor with a heterogeneous presentation, incompletely understood pathogenesis, and generally poor prognosis, occurs in 1-2 people per million and is even more uncommon in the pediatric population. Such rare cancers are a challenge to clinical practice. Exchange of experience, informa...

journal_title：Molecular and cellular endocrinology

authors： Ribeiro RC,Pinto EM,Zambetti GP,Rodriguez-Galindo C

更新日期：2012-03-31 00:00:00

abstract：:Mineralocorticoid receptor (MR) signaling is pivotal for numerous physiological processes and implicated in various pathological conditions concerning among others, tight epithelia, central nervous and cardiovascular systems. For decades, the pleiotropic actions of MR have been investigated using animal and cellular m...

journal_title：Molecular and cellular endocrinology

authors： Le Menuet D,Munier M,Campostrini G,Lombès M

更新日期：2012-03-24 00:00:00

abstract：:Peroxisome proliferator-activated receptors (PPAR)α have been shown to exert immunomodulatory effects in autoimmune disorders; no study evaluated the effect of PPARα activation in Graves' ophthalmopathy (GO). We show the presence of PPARα, δ and γ in GO fibroblasts and preadipocytes. PPARα activators have a potent inh...

journal_title：Molecular and cellular endocrinology

authors： Antonelli A,Ferrari SM,Frascerra S,Ruffilli I,Gelmini S,Minuto M,Pupilli C,Miccoli P,Sellari-Franceschini S,Ferrannini E,Fallahi P

更新日期：2012-02-26 00:00:00

abstract：:Although well-established, the underlying mechanisms involved in obesity-related plasma adiponectin decline remain elusive. Oxidative stress is associated with obesity and insulin resistance and considered to contribute to the progression toward obesity-related metabolic disorders. In this study, we investigated the e...

journal_title：Molecular and cellular endocrinology

authors： Wang Z,Dou X,Gu D,Shen C,Yao T,Nguyen V,Braunschweig C,Song Z

更新日期：2012-02-26 00:00:00

abstract：:In recent years it has become evident that glucocorticoid receptor (GR) action in the nucleus is highly dynamic, characterized by a rapid exchange at the chromatin template. This stochastic mode of GR action couples perfectly with a deterministic pulsatile availability of endogenous ligand in vivo. The endogenous gluc...

journal_title：Molecular and cellular endocrinology

authors： Conway-Campbell BL,Pooley JR,Hager GL,Lightman SL

更新日期：2012-01-30 00:00:00

abstract：:Secretin and the secretin receptor have been reported to play an important role in regulating pancreatic water and bicarbonate secretion in mammals; however, little is known about their expression, structure, and biological functions in non-mammalian vertebrates including birds. In this study, the full-length cDNAs en...

journal_title：Molecular and cellular endocrinology

authors： Wang Y,Huang G,Li J,Meng F,He X,Leung FC

更新日期：2012-01-02 00:00:00

abstract：:Since all-trans retinoic acid (ATRA) has shown promising results in differentiation therapy, the present study was designed to investigate the effects of ATRA on thyroid carcinoma and to evaluate the effectiveness of ATRA in redifferentiation induction of thyroid carcinoma. Therefore, we investigated cell growth rate,...

journal_title：Molecular and cellular endocrinology

authors： Malehmir M,Haghpanah V,Larijani B,Ahmadian S,Alimoghaddam K,Heshmat R,Ghavamzadeh A,Adabi K,Ghaffari SH

更新日期：2012-01-02 00:00:00

abstract：:Neuropeptide Y (NPY) is expressed in adipose tissue and is involved in adipocyte metabolism. Although NPY impacts on glucose utilization in vivo, the underlying cellular mechanism is yet to be fully elucidated. In this study we investigated the effect of NPY on the insulin-stimulated translocation of glucose transport...

journal_title：Molecular and cellular endocrinology

authors： Gericke MT,Schröder T,Kosacka J,Nowicki M,Klöting N,Spanel-Borowski K

更新日期：2012-01-02 00:00:00

abstract：:Melanocortin 4 receptors (MC4R) are mainly expressed in the brain. We previously showed that the anti-inflammatory action of α-melanocyte-stimulating hormone (α-MSH) in rat hypothalamus and in cultured astrocytes involved MC4R activation. However, MC4R mechanisms of action remain undetermined. Since brain-derived neur...

journal_title：Molecular and cellular endocrinology

authors： Caruso C,Carniglia L,Durand D,Gonzalez PV,Scimonelli TN,Lasaga M

更新日期：2012-01-02 00:00:00

abstract：:1,25-Dihydroxyvitamin D (1,25(OH)(2)D) plays a critical role in calcium and phosphorus (Pi) metabolism, bone growth, and tissue differentiation. The synthesis of 1,25(OH)(2)D in the proximal renal tubule is the primary determinant of its circulating concentration and is mediated by the mitochondrial enzyme, 25-hydroxy...

journal_title：Molecular and cellular endocrinology

authors： Perwad F,Portale AA

更新日期：2011-12-05 00:00:00

abstract：:The endocrine activity of 1,25-dihydroxyvitamin D (1,25(OH)(2)D(3)) contributes to maintaining plasma calcium and phosphate homeostasis through actions on the intestine, kidney and bone. A significant body of evidence has been published over the last 10 years indicating that all major bone cells have the capacity to m...

journal_title：Molecular and cellular endocrinology

authors： Anderson PH,Atkins GJ,Turner AG,Kogawa M,Findlay DM,Morris HA

更新日期：2011-12-05 00:00:00

abstract：:Non-alcoholic fatty liver disease (NAFLD) is associated with hepatic insulin resistance with the molecular basis of this association being not well understood. Here we studied the effect of hepatic triglyceride accumulation induced by postprandial triglyceride-rich lipoproteins (TGRL) on hepatic insulin sensitivity in...

journal_title：Molecular and cellular endocrinology

authors： Tatarczyk T,Ciardi C,Niederwanger A,Kranebitter M,Patsch JR,Pedrini MT

更新日期：2011-08-22 00:00:00